Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock
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منابع مشابه
Cellular Mechanisms of MOF During Severe Sepsis and Septic Shock
Severe sepsis and septic shock continue to plague intensive care units, leading to significant morbidity and mortality (Vincent et al., 2007). During the pathogenesis of sepsis, patients often develop multiple organ failure (MOF), which is believed to be the main cause of death (Vincent et al., 2007), indicating that either treatment or prevention of MOF could have profound therapeutic implicat...
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ISSN: 2155-9864 JBDT, an open access journal Sepsis: Pathophysiology & Management J Blood Disord Transfus Severity of illness and the inherent mortality risk escalate from SIRS, through sepsis, severe sepsis and septic shock to multi-organ failure. Mortality estimates vary, but Severe Sepsis and Septic Shock carry high potential mortality rates, possibly up to 46% [2]. The number of sepsisrelat...
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Among the different conditions of critical illness leading to admission to an Intensive Care Unit (ICU), sepsis remains the leading cause of death at the non-coronary medical ICU [1]. Even with optimal therapy, mortality rates of severe sepsis and septic shock are about 40 to 50% [2, 3]. Although there are numerous studies with varying methods from different countries, the incidence of severe s...
متن کاملSevere sepsis and septic shock
Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Se...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.00920